Asian Journal of Research in Chemistry

Sunil Singh ¹, Nitin Dubey ¹, D. K. Jain ¹

Affiliations
1 College of Pharmacy, IPS Academy, Rajendar Nagar, Indore [Madhya Pradesh], IN

Abstract

Atorvastatin [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino)carbonyl]-1H-pyrrole 1-heptanoic acid an Anti-hyperlipidemia and Clopidogrel (2-Chloro phenyl, 6-7 dihydro4H thieno [3,2-c]pyridine-5-yl)acetic acid is an Anti-platelet drug and Aspirin (2-Acetoxy benzoic acid) an NSAIDs. This paper presents two methods i.e. first derivative spectrophotometery and multicomponent spectrophotometery for simultaneous estimation of these three drugs combination in pharmaceutical formulations. The first derivative amplitudes at 276, 226 and 222 nm were utilized for simultaneous estimations. The multicomponent amplitudes at 247, 220 and 235 nm were utilizatied. Proper selection of wavelength for estimations of one drug by other in derivative spectra and multicomponent lead to successful development of methods for simultaneous estimation. The results of analysis were validated statistically that included parameters such as precision, LOD, LOQ, recovery and robustness. Both methods were simple, economical, accurate, reproducible and precise.

Keywords

Simultaneous Determination, Derivative Spectroscopy, Multicomponent Method.

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Jain Sachin ¹, Jain Neetesh ¹, A. Tiwari ¹, N. Balekar ¹, D. K. Jain ¹

Affiliations
1 College of Pharmacy, IPS Academy, Rajendra Nagar, Indore (M.P.), IN

Abstract

The present study was aim to investigate the possible effect of Ageratum conyzoides ischolar_main extract on wound healing and is also include a comparable study of effect of polyherbal formulation containing Ageratum conyzoides, Ficus religiosa, Curcuma longa and Tamarindus indica, on wound healing process with respect to intact plant formulation through topical route. The wound healing property of Ageratum conyzoides appears to be due to the presence of its active principles, which accelerates the healing process and confers breaking strength to the healed wound. Further, wound healing activity by polyherbal formulation was found to be better than ageratum treated groups in rat. It may be attributed to the synergistic action of ageratum constituent and the constituent of other plants present in the polyherbal formulation.

Keywords

Ageratum conyzoides, Wound Healing.

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Nitin Dubey ¹, Nidhi Dubey ², R. S. Mehta ³, A. K. Saluja ³, D. K. Jain ¹

Affiliations
1 College of Pharmacy, IPS Academy, Indore [M.P], IN
2 School of Pharmacy, Devi Ahilya University, Indore [M.P], IN
3 A R College of Pharmacy, Vallabh Vidyanagar [Gujarat], IN

Abstract

Kushta-e-gaodanti was prepared as per the method mentioned in Unani formulary. The raw materials, intermediates obtained during the preparation of kushta and the final product were characterized using modern analytical techniques like Fourier transform infra-red spectroscopy (FTIR). X-ray powder diffraction (XRPD) and thermo gravimetric analysis (TGA). The study shows that the mineral Gaodanti (calcium sulphate dihydrate) is converted into calcium sulphate hemi hydrate on first calcination in earthen pot sealed with the process gil-e-hikmat. Further on calcination this intermediate is transformed to kushta-e-gaodanti which is orthorhombic α-calcium sulphate anhydride. Kushta-e-gaodanti is a fine powder with particle size 7-8 micrometer, calcium content 29.32%, bulk density 0.928, tapped density 1.268, angle of repose 36.67° and the value of Carr’s index is 47.08. Loss on drying at 110°C and loss on ignition was not more than 0.5 %w/w and 0.05% w/w respectively. Microbial load of the preparation was found negative for the presence of Escherichia coli, Salmonella species and Staphylococcus aureus. Total aerobic count was under acceptance limit. Trace element analysis of bhasma by ICP-OES revealed the presence of some other important metals like arsenic, lead, chromium, cadmium, mercury, tin under acceptable limits at prescribed dose.

Keywords

FTIR, Calcination, Unani Traditional Medicine.

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